Monterey Peninsula College
CHEM 30B
Dr. R. Rinehart

Enzyme Web Tour

At Kimball's Biology Pages, check out the section on lysozyme and its mechanism of action at
http://www.ultranet.com/~jkimball/BiologyPages/E/Enzymes.html
and then see the lysozyme Chime structure by Will McClure at Carnegie Mellon University
http://www.bio.cmu.edu/Courses/BiochemMols/BuildBlocks/lysozyme.html

See an illustrated discussion of the chymotrypsin mechanism by Mark Bishop of MPC at
http://www.mpcfaculty.net/mark_bishop/chymotrypsin.htm

Trypsin structure and action tutorials from Carnegie Mellon University [Use Netscape 4.7x]
http://www.bio.cmu.edu/Courses/03231/psetF04/pset9/trypsin.htm by Gordon Rule
and
http://www.bio.cmu.edu/courses/03231/chime_tut/chime.html > 3: Catalytic Triad in Trypsin
by Dr. David Hackney and Dr. W. McClure
With Chime With Chime/Rasmol

also see: serprot.htm trypsin.htm

The serine proteases by Peter Birch at University of Paisley, UK
step-by-step explanation of the reaction itself, including the basic chemistry involved and the catalytic mechanism
http://www-biol.paisley.ac.uk/courses/mechenz/serprot/chymcat_frame.html
also mirrored at
http://instruct1.cit.cornell.edu/courses/biobm330/serprot/serprot/chymchime_frame.html
AND
Chime tutorial of chymotrypsin by Peter Birch at University of Paisley, UK [Use Netscape 4.7x]
http://www-biol.paisley.ac.uk/courses/mechenz/serprot/chymchime_frame.html
also mirrored at
http://instruct1.cit.cornell.edu/courses/biobm330/serprot/serprot/chymchime_frame.html

After reading that, you will better appreciate the animated serine protease mechanism
from Gordon Rule's course at Carnegie Mellon University at
http://www.bio.cmu.edu/Courses/03231/Movies/chymotrypsin%20animation.mov
http://info.bio.cmu.edu/courses/03231/Protease/SerPro.htm

Go to the Interactive Biochemistry Pages at the University of Virginia,
http://cti.itc.virginia.edu/~cmg/Demo/molecule.html
and look at the tutorials on
HIV-1 Protease,
P53-A Tumor Suppressor Protein, and
Cyclooxygenases and the Mechanism of Action of Aspirin and NSAIDs

http://stingray.bio.cmu.edu/~web/bc/Lec/Lec16/trypsin.htm
http://stingray.bio.cmu.edu/~web/bc1/trypsin/trypsin.htm

Succinate dehydrogenase page at CMU
http://stingray.bio.cmu.edu/~web/bc1/sdh/sdh.htm

http://www.bio.cmu.edu/Courses/BiochemMols/